PDBsum entry 8s9p

Signaling protein

PDB id: 8s9p

Contents

Protein chains

178 a.a.

914 a.a.

97 a.a.

PDB id:

8s9p

Name:

Signaling protein

Title:

1:1:1 agrin/lrp4/musk complex

Structure:

Agrin. Chain: a. Engineered: yes. Low-density lipoprotein receptor-related protein 4. Chain: b. Synonym: lrp-4,multiple epidermal growth factor-like domains 7. Engineered: yes. Muscle, skeletal receptor tyrosine-protein kinase. Chain: c.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: agrn, agrin. Expressed in: homo sapiens. Expression_system_taxid: 9606. Gene: lrp4, kiaa0816, lrp10, megf7. Gene: musk. Expression_system_taxid: 9606

Authors:

T.Xie,G.J.Xu,Y.Liu,B.Quade,W.C.Lin,X.C.Bai

Key ref:

T.Xie et al. Structural insights into the assembly of the agrin/lr signaling complex. To be published, . PubMed id: 37252960

Date:

29-Mar-23 Release date: 17-May-23

Protein chain

O00468  (AGRIN_HUMAN) -  Agrin from Homo sapiens

Seq: 2068 a.a.

Struc: 178 a.a.

Protein chain

O75096  (LRP4_HUMAN) -  Low-density lipoprotein receptor-related protein 4 from Homo sapiens

Seq: 1905 a.a.

Struc: 914 a.a.

Protein chain

O15146  (MUSK_HUMAN) -  Muscle, skeletal receptor tyrosine-protein kinase from Homo sapiens

Seq: 869 a.a.

Struc: 97 a.a.

Enzyme reactions

• Enzyme class: Chain C: E.C.2.7.10.1 - receptor protein-tyrosine kinase.
• Reaction: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site