PDBsum entry 8s9h

Immune system

PDB id: 8s9h

Contents

Protein chains

768 a.a.

Ligands

NAG-NAG-BMA

NAG-NAG ×3

NAG ×14

ZWV ×2

SO4 ×2

Waters ×711

PDB id:

8s9h

Name:

Immune system

Title:

Crystal structure of monkey tlr7 ectodomain with compound 14

Structure:

Toll-like receptor 7. Chain: a, b. Engineered: yes

Source:

Macaca mulatta. Rhesus monkey. Organism_taxid: 9544. Gene: tlr7. Expressed in: drosophila melanogaster. Expression_system_taxid: 7227

Resolution:

2.44Å R-factor: 0.248 R-free: 0.270

Authors:

D.A.Critton

Key ref:

L.He et al. Identification and optimization of small molecule pyrazolopyrimidine tlr7 agonists for applications in immuno-Oncology. Acs med chem lett, . PubMed id: 38352849

Date:

28-Mar-23 Release date: 07-Feb-24

Protein chains

B3Y653  (B3Y653_MACMU) -  Toll-like receptor 7 from Macaca mulatta

Seq: 1049 a.a.

Struc: 768 a.a.*

* PDB and UniProt seqs differ at 3 residue positions (black crosses)