PDBsum entry 8s9c

Membrane protein

PDB id: 8s9c

Contents

Protein chains

1273 a.a.

173 a.a.

119 a.a.

Ligands

NAG-NAG ×3

NAG ×5

N6W

P5S ×3

Y01 ×5

LPE ×9

PCW ×4

Waters ×20

PDB id:

8s9c

Name:

Membrane protein

Title:

Cryo-em structure of nav1.7 with cbz

Structure:

Sodium channel protein type 9 subunit alpha. Chain: a. Synonym: neuroendocrine sodium channel,hne-na,peripheral sodium channel 1,pn1,sodium channel protein type ix subunit alpha,voltage- gated sodium channel subunit alpha nav1.7. Engineered: yes. Other_details: carbamazepine. Sodium channel subunit beta-1. Chain: b.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: scn9a, nena. Expressed in: homo sapiens. Expression_system_taxid: 9606. Gene: scn1b. Gene: scn2b, unq326/pro386. Expression_system_taxid: 9606

Authors:

X.Fan,J.Huang,N.Yan

Key ref:

Q.Wu et al. (2023). Structural mapping of na V 1.7 antagonists.. Nat commun, 14, 3224. PubMed id: 37270609

Date:

27-Mar-23 Release date: 30-Aug-23

Protein chain

Q15858  (SCN9A_HUMAN) -  Sodium channel protein type 9 subunit alpha from Homo sapiens

Seq: 1988 a.a.

Struc: 1273 a.a.

Protein chain

Q07699  (SCN1B_HUMAN) -  Sodium channel regulatory subunit beta-1 from Homo sapiens

Seq: 218 a.a.

Struc: 173 a.a.

Protein chain

O60939  (SCN2B_HUMAN) -  Sodium channel regulatory subunit beta-2 from Homo sapiens

Seq: 215 a.a.

Struc: 119 a.a.