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PDBsum entry 8s98
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PDB id:
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Transferase
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Title:
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Crystal structure of the tyk2 pseudokinase domain in complex with compound 8
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Structure:
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Non-receptor tyrosine-protein kinase tyk2. Chain: a, b, c. Engineered: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: tyk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
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Resolution:
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1.87Å
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R-factor:
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0.226
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R-free:
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0.274
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Authors:
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A.V.Toms,S.Leit,J.R.Greenwood,S.Carriero,S.Mondal,R.Abel,M.Ashwell, H.Blanchette,N.Boyles,M.Cartwright,A.Collis,S.Feng,P.Ghanakota, G.C.Harriman,V.Hosagrahara,N.Kaila,R.Kapeller,S.Rafi,D.L.Romero, P.Tarantino,J.Timaniya,R.T.Wester,W.Westlin,B.Srivastava,W.Miao, P.Tummino,J.J.Mcelwee,S.D.Edmondson,C.E.Massee
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Key ref:
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S.Leit
et al.
Discovery of a potent and selective tyrosine kinase 2 inhibitor: tak-279..
J med chem,
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PubMed id:
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Date:
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27-Mar-23
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Release date:
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26-Jul-23
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PROCHECK
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Headers
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References
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P29597
(TYK2_HUMAN) -
Non-receptor tyrosine-protein kinase TYK2 from Homo sapiens
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Seq:
Struc:
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1187 a.a.
256 a.a.*
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Key: |
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Secondary structure |
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*
PDB and UniProt seqs differ
at 1 residue position (black
cross)
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Enzyme class:
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E.C.2.7.10.2
- non-specific protein-tyrosine kinase.
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Reaction:
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L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H+
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L-tyrosyl-[protein]
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+
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ATP
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=
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O-phospho-L-tyrosyl-[protein]
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+
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ADP
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+
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H(+)
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Links
