PDBsum entry 8s8o

Protein binding

PDB id: 8s8o

Contents

Protein chains

52 a.a.

28 a.a.

PDB id:

8s8o

Name:

Protein binding

Title:

Solution structure of camp-dependent protein kinase rii-alpha subunit dimerization and docking domain complex with microtubule associated protein 2c (84-111)

Structure:

Camp-dependent protein kinase type ii-alpha regulatory subunit. Chain: a, b. Fragment: n-terminal docking and dimerization domain, residues 1-52. Engineered: yes. Isoform 3 of microtubule-associated protein 2. Chain: c. Fragment: n-terminal pka binding region, residues 80-120. Synonym: map-2.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: prkar2a, pkr2, prkar2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Expression_system_variant: ripl. Rattus norvegicus. Norway rat.

NMR struc:

20 models

Authors:

V.Bartosik,A.Lanikova,Z.Janackova,P.Padrta,L.Zidek

Key ref:

V.Bartosik et al. (2024). Structural basis of binding the unique n-Terminal dom microtubule-Associated protein 2c to proteins regulat kinases of signaling pathways.. J.Biol.Chem., 300, 07551. PubMed id: 39002671 DOI: 10.1016/J.JBC.2024.107551

Date:

06-Mar-24 Release date: 25-Sep-24

Protein chains

P13861  (KAP2_HUMAN) -  cAMP-dependent protein kinase type II-alpha regulatory subunit from Homo sapiens

Seq: 404 a.a.

Struc: 52 a.a.

Protein chain

P15146  (MTAP2_RAT) -  Microtubule-associated protein 2 from Rattus norvegicus

Seq: 1861 a.a.

Struc: 28 a.a.