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PDBsum entry 8s8a
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PDB id:
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Hydrolase
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Title:
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Human pyridoxal phosphatase in complex with 7,8-dihydroxyflavone without phosphate
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Structure:
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Chronophin. Chain: a. Synonym: pyridoxal phosphate phosphatase,plp phosphatase. Engineered: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: pdxp, cin, plp, plpp. Expressed in: escherichia coli. Expression_system_taxid: 562
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Resolution:
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1.50Å
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R-factor:
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0.183
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R-free:
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0.205
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Authors:
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M.Brenner,A.Gohla,H.Schindelin
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Key ref:
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M.Brenner
et al.
(2024).
7,8-Dihydroxyflavone is a direct inhibitor of pyridox phosphatase.
Elife,
3094,
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PubMed id:
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Date:
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06-Mar-24
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Release date:
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12-Jun-24
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PROCHECK
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Headers
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References
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Q96GD0
(PLPP_HUMAN) -
Chronophin from Homo sapiens
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Seq:
Struc:
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296 a.a.
294 a.a.
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Enzyme class 1:
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E.C.3.1.3.16
- protein-serine/threonine phosphatase.
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Reaction:
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1.
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O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate
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2.
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O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate
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O-phospho-L-seryl-[protein]
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+
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H2O
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=
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L-seryl-[protein]
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+
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phosphate
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O-phospho-L-threonyl-[protein]
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+
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H2O
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=
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L-threonyl-[protein]
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+
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phosphate
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Enzyme class 2:
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E.C.3.1.3.74
- pyridoxal phosphatase.
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Reaction:
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pyridoxal 5'-phosphate + H2O = pyridoxal + phosphate
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pyridoxal 5'-phosphate
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+
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H2O
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=
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pyridoxal
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+
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phosphate
Bound ligand (Het Group name = )
matches with 40.91% similarity
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Cofactor:
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Mg(2+)
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Note, where more than one E.C. class is given (as above), each may
correspond to a different protein domain or, in the case of polyprotein
precursors, to a different mature protein.
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Links
