PDBsum entry 8s7x

Oxidoreductase

PDB id: 8s7x

Contents

Protein chains

259 a.a.

442 a.a.

550 a.a.

114 a.a.

495 a.a.

296 a.a.

194 a.a.

499 a.a.

47 a.a.

Ligands

F43 ×2

SHT

COM

TP7

S5Q ×3

PDB id:

8s7x

Name:

Oxidoreductase

Title:

Methyl-coenzyme m reductase activation complex without the a2 component

Structure:

Methyl-coenzyme m reductase subunit gamma. Chain: a, b. Other_details: methyl-coenzyme m reductase subunit gamma. Methyl-coenzyme m reductase subunit beta. Chain: e, d. Synonym: coenzyme-b sulfoethylthiotransferase beta. Other_details: methyl-coenzyme m reductase subunit beta. Methyl-coenzyme m reductase subunit alpha. Chain: c, f.

Source:

Methanococcus maripaludis. Organism_taxid: 39152. Strain: jj -upt. Gene: gyy_08635. Expressed in: methanococcus maripaludis. Expression_system_taxid: 39152. Strain: jj -upt

Authors:

F.Ramirez-Amador,S.Paul,A.Kumar,J.M.Schuller

Key ref:

F.Ramirez-Amador et al. Methyl-Coenzyme m reductase activation complex withou a2 component. To be published, . PubMed id: 40240609

Date:

04-Mar-24 Release date: 26-Feb-25

Protein chains

A0A2L1CBG2  (A0A2L1CBG2_METMI) -  Methyl-coenzyme M reductase subunit gamma from Methanococcus maripaludis

Seq: 260 a.a.

Struc: 259 a.a.

Protein chains

A0A2L1CBB3  (A0A2L1CBB3_METMI) -  Methyl-coenzyme M reductase subunit beta from Methanococcus maripaludis

Seq: 443 a.a.

Struc: 442 a.a.

Protein chain

A0A2L1CBB0  (A0A2L1CBB0_METMI) -  Methyl-coenzyme M reductase subunit alpha from Methanococcus maripaludis

Seq: 553 a.a.

Struc: 550 a.a.*

Protein chain

G0H411  (G0H411_METMI) -  Methanogenesis marker protein 17 from Methanococcus maripaludis X1

Seq: 183 a.a.

Struc: 114 a.a.*

Protein chain

A0A2L1CBB0  (A0A2L1CBB0_METMI) -  Methyl-coenzyme M reductase subunit alpha from Methanococcus maripaludis

Seq: 553 a.a.

Struc: 495 a.a.*

Protein chain

A0A2L1C9H0  (A0A2L1C9H0_METMI) -  Methyl-coenzyme M reductase operon protein C from Methanococcus maripaludis

Seq: 304 a.a.

Struc: 296 a.a.

Protein chain

G0H3B1  (G0H3B1_METMI) -  Methyl-coenzyme M reductase operon protein C from Methanococcus maripaludis X1

Seq: 198 a.a.

Struc: 194 a.a.

Protein chain

A0A7J9PIK9  (A0A7J9PIK9_METMI) -  UPF0288 protein HNP90_001391 from Methanococcus maripaludis

Seq: 501 a.a.

Struc: 499 a.a.*

Protein chain

A0A2L1CAX0  (A0A2L1CAX0_METMI) -  DUF2098 domain-containing protein from Methanococcus maripaludis

Seq: 93 a.a.

Struc: 47 a.a.

* PDB and UniProt seqs differ at 45 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chains A, B, E, D, C, F: E.C.2.8.4.1 - coenzyme-B sulfoethylthiotransferase.
• Pathway: Methane Biosynthesis
• Reaction: coenzyme B + methyl-coenzyme M = methane + coenzyme M-coenzyme B heterodisulfide

coenzyme B (Bound ligand (Het Group name = SHT) matches with 75.00% similarity) + methyl-coenzyme M (Bound ligand (Het Group name = COM) matches with 87.50% similarity) = methane + coenzyme M-coenzyme B heterodisulfide

• Cofactor: Coenzyme F430

Coenzyme F430 (Bound ligand (Het Group name = F43) matches with 96.83% similarity)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site