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PDBsum entry 8s6f
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Viral protein
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PDB id
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8s6f
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PDB id:
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| Name: |
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Viral protein
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Title:
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A structural investigation of the interaction between a gc-376-based peptidomimetic protac and its precursor with the viral main protease of coxsackievirus b3
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Structure:
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Protease 3c. Chain: a. Synonym: picornain 3c,p3c. Engineered: yes
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Source:
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Coxsackievirus b3. Organism_taxid: 12072. Expressed in: escherichia coli. Expression_system_taxid: 562
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Resolution:
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1.93Å
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R-factor:
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0.240
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R-free:
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0.264
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Authors:
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A.De Santis,D.Grifagni,A.Orsetti,E.Lenci,A.Rosato,M.D'Onofrio, A.Trabocchi,S.Ciofi-Baffoni,F.Cantini,V.Calderone
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Key ref:
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A.De santis
et al.
(2024).
A structural investigation of the interaction between gc-376-Based peptidomimetic protac and its precursor the viral main protease of coxsackievirus b3..
Biomolecules,
14,
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PubMed id:
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Date:
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27-Feb-24
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Release date:
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04-Dec-24
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PROCHECK
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Headers
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References
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P03313
(POLG_CXB3N) -
Genome polyprotein from Coxsackievirus B3 (strain Nancy)
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Seq:
Struc:
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2185 a.a.
180 a.a.
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Key: |
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PfamA domain |
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Secondary structure |
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Enzyme class 2:
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E.C.2.7.7.48
- RNA-directed Rna polymerase.
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Reaction:
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RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate
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RNA(n)
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+
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ribonucleoside 5'-triphosphate
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=
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RNA(n+1)
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+
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diphosphate
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Enzyme class 3:
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E.C.3.4.22.28
- picornain 3C.
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Reaction:
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Selective cleavage of Gln-|-Gly bond in the poliovirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly.
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Enzyme class 4:
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E.C.3.4.22.29
- picornain 2A.
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Reaction:
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Selective cleavage of Tyr-|-Gly bond in the picornavirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly.
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Enzyme class 5:
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E.C.3.6.1.15
- nucleoside-triphosphate phosphatase.
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Reaction:
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a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + phosphate + H+
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ribonucleoside 5'-triphosphate
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+
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H2O
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=
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ribonucleoside 5'-diphosphate
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+
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phosphate
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+
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H(+)
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Note, where more than one E.C. class is given (as above), each may
correspond to a different protein domain or, in the case of polyprotein
precursors, to a different mature protein.
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Links
