PDBsum entry 8s1o

Signaling protein

PDB id: 8s1o

Contents

Protein chain

175 a.a.

Ligands

GDP

PO4

Metals

_MG

Waters ×52

PDB id:

8s1o

Name:

Signaling protein

Title:

Crystal structure of human rac1-gdp-pi

Structure:

Ras-related c3 botulinum toxin substrate 1. Chain: a. Synonym: cell migration-inducing gene 5 protein,ras-like protein tc25,p21-rac1. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: rac1, tc25, mig5. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008

Resolution:

2.27Å R-factor: 0.211 R-free: 0.266

Authors:

Y.Ferrandez,J.Cherfils

Key ref:

Y.Ferrandez and j.cherfils Crystal structure of human rac1-Gdp-Pi. To be published, .

Date:

15-Feb-24 Release date: 03-Sep-25

Protein chain

P63000  (RAC1_HUMAN) -  Ras-related C3 botulinum toxin substrate 1 from Homo sapiens

Seq: 192 a.a.

Struc: 175 a.a.*

* PDB and UniProt seqs differ at 1 residue position (black cross)

Enzyme reactions

• Enzyme class: E.C.3.6.5.2 - small monomeric GTPase.
• Reaction: GTP + H2O = GDP + phosphate + H⁺

GTP + H2O = GDP (Bound ligand (Het Group name = GDP) corresponds exactly) + phosphate (Bound ligand (Het Group name = PO4) corresponds exactly) + H(+)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site