PDBsum entry 8s1m

Protein binding

PDB id: 8s1m

Contents

Protein chain

137 a.a.

Ligands

GOL

Metals

_CL

Waters ×26

PDB id:

8s1m

Name:

Protein binding

Title:

Crystal structure of human gabarap fused to egfr (1076-1099)

Structure:

Epidermal growth factor receptor,gamma-aminobutyric acid receptor-associated protein. Chain: a. Synonym: proto-oncogenE C-erbb-1,receptor tyrosine-protein kinase erbb-1,gaba(a) receptor-associated protein,mm46. Engineered: yes. Other_details: egfr(1052-1075) fused to n-terminus of gabarap, egfr(1052-1075) fused to n-terminus of gabarap,egfr(1052-1075) fused to n-terminus of gabarap,egfr(1052-1075) fused to n-terminus of

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1, gabarap, flc3b, ht004. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Expression_system_variant: t1

Resolution:

2.05Å R-factor: 0.206 R-free: 0.230

Authors:

A.Ueffing,D.Willbold,O.H.Weiergraeber

Key ref:

A.Ueffing et al. Crystal structure of human gabarap fused to egfr (107. To be published, . PubMed id: 39160442

Date:

15-Feb-24 Release date: 14-Aug-24

Protein chain

O95166  (GBRAP_HUMAN) -  Gamma-aminobutyric acid receptor-associated protein from Homo sapiens

Seq: 117 a.a.

Struc: 137 a.a.

Protein chain

P00533  (EGFR_HUMAN) -  Epidermal growth factor receptor from Homo sapiens

Seq: 1210 a.a.

Struc: 137 a.a.*

* PDB and UniProt seqs differ at 99 residue positions (black crosses)

Enzyme reactions

• Enzyme class: E.C.2.7.10.1 - receptor protein-tyrosine kinase.
• Reaction: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site