PDBsum entry 8s17

Transferase

PDB id: 8s17

Contents

Protein chains

305 a.a.

284 a.a.

Ligands

0LI ×2

Metals

_CL ×4

Waters ×177

PDB id:

8s17

Name:

Transferase

Title:

C-kit kinase domain in complex with ponatinib

Structure:

Mast/stem cell growth factor receptor kit. Chain: a, b. Synonym: scfr,piebald trait protein,pbt,proto-oncogenE C-kit, tyrosine-protein kinase kit,p145 c-kit,v-kit hardy-zuckerman 4 feline sarcoma viral oncogene homolog. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: kit, scfr. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008

Resolution:

2.20Å R-factor: 0.203 R-free: 0.228

Authors:

A.Teuber,M.P.Mueller,D.Rauh

Key ref:

A.Teuber et al. C-Kit kinase domain in complex with ponatinib. To be published, .

Date:

15-Feb-24 Release date: 03-Sep-25

Protein chain

P10721  (KIT_HUMAN) -  Mast/stem cell growth factor receptor Kit from Homo sapiens

Seq: 976 a.a.

Struc: 305 a.a.*

Protein chain

P10721  (KIT_HUMAN) -  Mast/stem cell growth factor receptor Kit from Homo sapiens

Seq: 976 a.a.

Struc: 284 a.a.*

* PDB and UniProt seqs differ at 38 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain A: E.C.2.7.10.1 - receptor protein-tyrosine kinase.
• Reaction: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site