PDBsum entry 8roh

Nuclear protein

PDB id: 8roh

Contents

Protein chains

413 a.a.

87 a.a.

Ligands

SO4 ×3

GOL

Waters ×9

PDB id:

8roh

Name:

Nuclear protein

Title:

Human cohesin smc3-hd(eq)/rad21-n complex - apo conformation

Structure:

Structural maintenance of chromosomes protein 3. Chain: a. Synonym: smc protein 3,smc-3,basement membrane-associated chondroitin proteoglycan,bamacan,chondroitin sulfate proteoglycan 6,chromosome- associated polypeptide,hcap. Engineered: yes. Mutation: yes. Double-strand-break repair protein rad21 homolog. Chain: b.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: smc3, bam, bmh, cspg6, smc3l1. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: rad21, hr21, kiaa0078, nxp1, scc1. Expression_system_taxid: 562

Resolution:

2.60Å R-factor: 0.218 R-free: 0.255

Authors:

M.Vitoria Gomes,C.Romier

Key ref:

M.Vitoria gomes and c.romier The cohesin atpase cycle is mediated by specific conformational dynamics and interface plasticity of s and smc3 atpase domains. To be published, . PubMed id: 39240714

Date:

11-Jan-24 Release date: 11-Sep-24

Protein chain

Q9UQE7  (SMC3_HUMAN) -  Structural maintenance of chromosomes protein 3 from Homo sapiens

Seq: 1217 a.a.

Struc: 413 a.a.*

Protein chain

O60216  (RAD21_HUMAN) -  Double-strand-break repair protein rad21 homolog from Homo sapiens

Seq: 631 a.a.

Struc: 87 a.a.

* PDB and UniProt seqs differ at 190 residue positions (black crosses)