PDBsum entry 8qtx

Hydrolase

PDB id: 8qtx

Contents

Protein chain

527 a.a.

Ligands

NAG-FUC ×3

NAG-NAG-FUC ×2

GOL ×2

NAG

MES

WXN

CO3

SO4 ×6

Waters ×172

PDB id:

8qtx

Name:

Hydrolase

Title:

Structure of human butyrylcholinesterase with 3-(((2- cycloheptylethyl)(methyl)amino)methyl)-n-methyl-1h-indol-7-amine

Structure:

Cholinesterase. Chain: a. Synonym: acylcholine acylhydrolase,butyrylcholine esterase,choline esterase ii,pseudocholinesterase. Engineered: yes. Mutation: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: bche, che1. Expressed in: cricetulus griseus. Expression_system_taxid: 10029

Resolution:

2.12Å R-factor: 0.180 R-free: 0.216

Authors:

X.Brazzolotto,A.Meden,D.Knez,S.Gobec,F.Nachon

Date:

13-Oct-23 Release date: 23-Oct-24

Protein chain

P06276  (CHLE_HUMAN) -  Cholinesterase from Homo sapiens

Seq: 602 a.a.

Struc: 527 a.a.*

* PDB and UniProt seqs differ at 4 residue positions (black crosses)

Enzyme reactions

• Enzyme class: E.C.3.1.1.8 - cholinesterase.
• Reaction: an acylcholine + H2O = a carboxylate + choline + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site