PDBsum entry 8qtg

Ligase

PDB id: 8qtg

Contents

Protein chain

384 a.a.

Ligands

WUQ

Metals

_NA

_ZN ×2

Waters ×294

PDB id:

8qtg

Name:

Ligase

Title:

Crystal structure of cbl-b in complex with an allosteric inhibitor (compound 9)

Structure:

E3 ubiquitin-protein ligase cbl-b. Chain: a. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: cblb. Expressed in: escherichia coli. Expression_system_taxid: 562

Resolution:

1.42Å R-factor: 0.209 R-free: 0.243

Authors:

M.Schimpl

Key ref:

A.M.Mfuh Discovery and optimization of aryl pyridones as cbl-B in-Hibitors. To be published, . PubMed id: 38227216

Date:

12-Oct-23 Release date: 10-Jan-24

Protein chain

Q13191  (CBLB_HUMAN) -  E3 ubiquitin-protein ligase CBL-B from Homo sapiens

Seq: 982 a.a.

Struc: 384 a.a.

Enzyme reactions

• Enzyme class: E.C.2.3.2.27 - RING-type E3 ubiquitin transferase.
• Reaction: S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N₆- ubiquitinyl-[acceptor protein]-L-lysine