PDBsum entry 8qnh

Ligase

PDB id: 8qnh

Contents

Protein chain

384 a.a.

Ligands

Z3N

Metals

_NA

_ZN ×2

Waters ×38

PDB id:

8qnh

Name:

Ligase

Title:

Crystal structure of the e3 ubiquitin ligase cbl-b with an allosteric inhibitor (wo2020264398 ex23)

Structure:

E3 ubiquitin-protein ligase cbl-b. Chain: a. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: cblb. Expressed in: escherichia coli. Expression_system_taxid: 562

Resolution:

2.00Å R-factor: 0.223 R-free: 0.248

Authors:

M.Schimpl

Key ref:

M.Schimpl Discovery of a novel benzodiazepine series of cbl-B inhibitors for the activation of immune response in c cell targeting. To be published, . PubMed id: 38116444

Date:

26-Sep-23 Release date: 22-Nov-23

Protein chain

Q13191  (CBLB_HUMAN) -  E3 ubiquitin-protein ligase CBL-B from Homo sapiens

Seq: 982 a.a.

Struc: 384 a.a.

Enzyme reactions

• Enzyme class: E.C.2.3.2.27 - RING-type E3 ubiquitin transferase.
• Reaction: S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N₆- ubiquitinyl-[acceptor protein]-L-lysine