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PDBsum entry 8q7e
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947 a.a.
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1030 a.a.
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14 a.a.
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76 a.a.
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895 a.a.
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PDB id:
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Ligase
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Title:
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Structure of cul9-rbx1 ubiquitin e3 ligase complex - hexameric assembly
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Structure:
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Cullin-9. Chain: a, b, e, f, i, j. Synonym: cul-9,ubch7-associated protein 1,p53-associated parkin-like cytoplasmic protein. Engineered: yes. E3 ubiquitin-protein ligase rbx1. Chain: c, d, g, h, k, l. Synonym: e3 ubiquitin-protein transferase rbx1,protein zyp,ring finger protein 75,ring-box protein 1,rbx1,regulator of cullins 1,
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: cul9, h7ap1, kiaa0708, parc. Expressed in: homo sapiens. Expression_system_taxid: 9606. Gene: rbx1, rnf75, roc1. Expression_system_taxid: 9606
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Authors:
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L.V.M.Hopf,D.Horn-Ghetko,B.A.Schulman
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Key ref:
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D.Horn-Ghetko
et al.
Noncanonical assembly, Neddylation and chimeric cullin-Ring/rbr ubiquitylation by the 1.8 mda cul9 e3 complex..
Nat struct mol biol,
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PubMed id:
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Date:
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16-Aug-23
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Release date:
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17-Apr-24
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PROCHECK
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Headers
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References
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Q8IWT3
(CUL9_HUMAN) -
Cullin-9 from Homo sapiens
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Seq:
Struc:
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2517 a.a.
947 a.a.
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Q8IWT3
(CUL9_HUMAN) -
Cullin-9 from Homo sapiens
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Seq:
Struc:
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2517 a.a.
1030 a.a.
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P62877
(RBX1_HUMAN) -
E3 ubiquitin-protein ligase RBX1 from Homo sapiens
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Seq:
Struc:
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108 a.a.
14 a.a.
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Enzyme class 1:
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Chains C, D, G, H, K, L:
E.C.2.3.2.27
- RING-type E3 ubiquitin transferase.
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Reaction:
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S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6- ubiquitinyl-[acceptor protein]-L-lysine
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Enzyme class 2:
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Chains C, D, G, H, K, L:
E.C.2.3.2.32
- cullin-RING-type E3 NEDD8 transferase.
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Reaction:
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S-[NEDD8-protein]-yl-[E2 NEDD8-conjugating enzyme]-L-cysteine + [cullin]- L-lysine = [E2 NEDD8-conjugating enzyme]-L-cysteine + N6-[NEDD8- protein]-yl-[cullin]-L-lysine
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Note, where more than one E.C. class is given (as above), each may
correspond to a different protein domain or, in the case of polyprotein
precursors, to a different mature protein.
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