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PDBsum entry 8pqh
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PDB id:
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Transferase
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Title:
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Pdgfra t674i mutant kinase domain in complex with avapritinib
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Structure:
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Platelet-derived growth factor receptor alpha. Chain: a. Synonym: pdgf-r-alpha,pdgfr-alpha,alpha platelet-derived growth factor receptor,alpha-type platelet-derived growth factor receptor, cd140 antigen-like family member a,cd140a antigen,platelet-derived growth factor alpha receptor,platelet-derived growth factor receptor 2,pdgfr-2. Engineered: yes. Mutation: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: pdgfra, pdgfr2, rhepdgfra. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
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Resolution:
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2.50Å
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R-factor:
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0.220
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R-free:
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0.249
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Authors:
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A.Teuber,S.Kleinboelting,M.P.Mueller,D.Rauh
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Key ref:
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A.Teuber
et al.
Avapritinib-Based sar studies reveal a binding pocket and pdgfra.
Nat commun,
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PubMed id:
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Date:
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11-Jul-23
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Release date:
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27-Dec-23
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PROCHECK
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Headers
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References
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P16234
(PGFRA_HUMAN) -
Platelet-derived growth factor receptor alpha from Homo sapiens
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Seq:
Struc:
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1089 a.a.
321 a.a.*
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Key: |
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PfamA domain |
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Secondary structure |
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*
PDB and UniProt seqs differ
at 1 residue position (black
cross)
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Enzyme class:
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E.C.2.7.10.1
- receptor protein-tyrosine kinase.
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Reaction:
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L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H+
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L-tyrosyl-[protein]
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+
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ATP
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=
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O-phospho-L-tyrosyl-[protein]
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+
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ADP
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+
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H(+)
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Links
