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PDBsum entry 8pqb
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PDB id:
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Transferase
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Title:
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C-kit kinase domain in complex with avapritinib derivative 8
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Structure:
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Mast/stem cell growth factor receptor kit. Chain: a. Synonym: scfr,piebald trait protein,pbt,proto-oncogenE C-kit, tyrosine-protein kinase kit,p145 c-kit,v-kit hardy-zuckerman 4 feline sarcoma viral oncogene homolog. Engineered: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: kit, scfr. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008
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Resolution:
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1.87Å
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R-factor:
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0.200
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R-free:
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0.234
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Authors:
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A.Teuber,J.Niggenaber,M.P.Mueller,D.Rauh
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Key ref:
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A.Teuber
et al.
Avapritinib-Based sar studies reveal a binding pocket and pdgfra.
Nat commun,
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PubMed id:
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Date:
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11-Jul-23
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Release date:
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27-Dec-23
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PROCHECK
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Headers
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References
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P10721
(KIT_HUMAN) -
Mast/stem cell growth factor receptor Kit from Homo sapiens
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Seq:
Struc:
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976 a.a.
280 a.a.*
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Key: |
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PfamA domain |
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Secondary structure |
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*
PDB and UniProt seqs differ
at 18 residue positions (black
crosses)
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Enzyme class:
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E.C.2.7.10.1
- receptor protein-tyrosine kinase.
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Reaction:
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L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H+
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L-tyrosyl-[protein]
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+
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ATP
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=
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O-phospho-L-tyrosyl-[protein]
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+
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ADP
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+
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H(+)
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Links
