spacer
spacer

PDBsum entry 8ovc
Go to PDB code: 
protein ligands metals Protein-protein interface(s) links
Electron transport PDB id
8ovc

 

 

 

 

Loading ...

 
JSmol PyMol  
Contents
Protein chains
223 a.a.
381 a.a.
535 a.a.
86 a.a.
184 a.a.
139 a.a.
552 a.a.
286 a.a.
66 a.a.
144 a.a.
146 a.a.
26 a.a.
23 a.a.
301 a.a.
68 a.a.
148 a.a.
25 a.a.
Ligands
UNK-UNK-UNK-UNK-
UNK-UNK-UNK ×2
HEC ×4
MQ9 ×10
WUO ×4
FES ×2
9YF ×4
HEM ×4
CDL ×16
7PH ×3
HEA ×4
9XX
PLM
Metals
_CU
_MG
_CA ×2
Waters ×249
PDB id:
8ovc
Name: Electron transport
Title: Respiratory supercomplex (iii2-iv2) from mycobacterium smegmatis
Structure: Cytochrome bc1 complex cytochromE C subunit. Chain: o, c. Engineered: yes. Cytochrome bc1 complex cytochromE C subunit. Chain: m, g. Engineered: yes. Cytochrome bc1 complex cytochrome b subunit. Chain: n, h. Synonym: cytochrome bc1 reductase complex subunit qcrb.
Source: Mycolicibacterium smegmatis. Organism_taxid: 1772. Atcc: 700084. Gene: msmeg_4261. Expressed in: mycolicibacterium smegmatis. Expression_system_taxid: 1772. Expression_system_atcc_number: 700084. Gene: msmeg_4263. Gene: msmeg_2575.
Authors: T.Kovalova,S.Krol,D.Sjostrand,D.Riepl,A.Gamiz-Hernandez,P.Brzezinski, V.Kaila,M.Hogbom
Key ref: D.Riepl et al. (2024). Long-Range charge transfer mechanism of the III 2 IV mycobacterial supercomplex.. Nat commun, 15, 5276. PubMed id: 38902248
Date:
25-Apr-23     Release date:   17-Jul-24    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chains
Pfam   ArchSchema ?
A0R050  (A0R050_MYCS2) -  Cytochrome bc1 complex cytochrome c subunit from Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155)
Seq:
Struc: 		268 a.a.
223 a.a.
Protein chains
Pfam   ArchSchema ?
A0R051  (A0R051_MYCS2) -  Cytochrome bc1 complex Rieske iron-sulfur subunit from Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155)
Seq:
Struc: 		408 a.a.
381 a.a.
Protein chains
Pfam   ArchSchema ?
A0R052  (A0R052_MYCS2) -  Cytochrome bc1 complex cytochrome b subunit from Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155)
Seq:
Struc: 		 
Seq:
Struc: 		546 a.a.
535 a.a.
Protein chains
Pfam   ArchSchema ?
A0QVH4  (A0QVH4_MYCS2) -  Transmembrane protein from Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155)
Seq:
Struc: 		84 a.a.
86 a.a.*
Protein chains
Pfam   ArchSchema ?
A0R049  (A0R049_MYCS2) -  Probable cytochrome c oxidase subunit 3 from Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155)
Seq:
Struc: 		203 a.a.
184 a.a.
Protein chains
Pfam   ArchSchema ?
A0R056  (A0R056_MYCS2) -  Cytochrome c oxidase polypeptide 4 from Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155)
Seq:
Struc: 		139 a.a.
139 a.a.
Protein chains
A0A2U9PNL2  (A0A2U9PNL2_MYCSE) -  Cytochrome c oxidase subunit 1 from Mycolicibacterium smegmatis (strain MKD8)
Seq:
Struc: 		 
Seq:
Struc: 		555 a.a.
552 a.a.
Protein chain
Pfam   ArchSchema ?
A0R057  (A0R057_MYCS2) -  cytochrome-c oxidase from Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155)
Seq:
Struc: 		341 a.a.
286 a.a.
Protein chain
A0R1B6  (A0R1B6_MYCS2) -  Uncharacterized protein from Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155)
Seq:
Struc: 		79 a.a.
66 a.a.
Protein chains
Pfam   ArchSchema ?
A0R1B5  (Y4692_MYCS2) -  Uncharacterized protein MSMEG_4692/MSMEI_4575 from Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155)
Seq:
Struc: 		157 a.a.
144 a.a.
Protein chain
A0R562  (A0R562_MYCS2) -  LpqE protein from Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155)
Seq:
Struc: 		186 a.a.
146 a.a.
Protein chain
Pfam   ArchSchema ?
A0QQQ1  (A0QQQ1_MYCS2) -  Superoxide dismutase [Cu-Zn] from Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155)
Seq:
Struc: 		236 a.a.
26 a.a.
Protein chains
No UniProt id for this chain
Struc: 23 a.a.
Protein chain
Pfam   ArchSchema ?
A0R057  (A0R057_MYCS2) -  cytochrome-c oxidase from Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155)
Seq:
Struc: 		341 a.a.
301 a.a.
Protein chain
A0R1B6  (A0R1B6_MYCS2) -  Uncharacterized protein from Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155)
Seq:
Struc: 		79 a.a.
68 a.a.
Protein chain
A0R562  (A0R562_MYCS2) -  LpqE protein from Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155)
Seq:
Struc: 		186 a.a.
148 a.a.
Protein chain
Pfam   ArchSchema ?
A0QQQ1  (A0QQQ1_MYCS2) -  Superoxide dismutase [Cu-Zn] from Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155)
Seq:
Struc: 		236 a.a.
25 a.a.
Key:    PfamA domain  Secondary structure
* PDB and UniProt seqs differ at 11 residue positions (black crosses)

 Enzyme reactions 
   Enzyme class 2: Chains O, M, N, C, G, H: E.C.7.1.1.8  - quinol--cytochrome-c reductase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: a quinol + 2 Fe(III)-[cytochrome c](out) = a quinone + 2 Fe(II)- [cytochrome c](out) + 2 H(+)(out)
quinol
 + 2 × Fe(III)-[cytochrome c](out)
 =
quinone
Bound ligand (Het Group name = PLM)
matches with 58.33% similarity 		+ 2 × Fe(II)- [cytochrome c](out)
 + 2 × H(+)(out)
   Enzyme class 3: Chains S, T, R, Q, J, K, L, X: E.C.7.1.1.9  - cytochrome-c oxidase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: 4 Fe(II)-[cytochrome c] + O2 + 8 H+(in) = 4 Fe(III)-[cytochrome c] + 2 H2O + 4 H+(out)
4 × Fe(II)-[cytochrome c]
 + 2 × O2
 + 8 × H(+)(in)
 = 4 × Fe(III)-[cytochrome c]
 + 2 × H2O
 + 4 × H(+)(out)
      Cofactor: Cu cation
   Enzyme class 4: Chains Y, c: E.C.1.15.1.1  - superoxide dismutase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: 2 superoxide + 2 H+ = H2O2 + O2
2 × superoxide
 + 2 × H(+)
 = 8 × H2O2
 + 4 × O2
      Cofactor: Fe cation or Mn(2+) or (Zn(2+) and Cu cation)
Note, where more than one E.C. class is given (as above), each may correspond to a different protein domain or, in the case of polyprotein precursors, to a different mature protein.
Molecule diagrams generated from .mol files obtained from the KEGG ftp site

 

 

spacer
spacer