PDBsum entry 8osm

Oncoprotein

PDB id: 8osm

Contents

Protein chain

166 a.a.

Ligands

GNP

PGE

Metals

_MG

Waters ×62

PDB id:

8osm

Name:

Oncoprotein

Title:

Gtpase hras in complex with zn-cyclen at 200 mpa pressure

Structure:

Gtpase hras. Chain: a. Fragment: gtpase hras n-terminally processed. Synonym: h-ras-1,ha-ras,transforming protein p21,c-h-ras,p21ras. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: hras, hras1. Expressed in: escherichia coli. Expression_system_taxid: 562.

Resolution:

2.05Å R-factor: 0.174 R-free: 0.224

Authors:

N.Colloc'H,E.Girard,T.Prange,H.R.Kalbitzer

Key ref:

E.Girard et al. High pressure promotes binding of the allosteric inhi zn2+-Cyclen in crystals of activated h-Ras.. Chemistry, . PubMed id: 38647362

Date:

19-Apr-23 Release date: 08-May-24

Protein chain

P01112  (RASH_HUMAN) -  GTPase HRas from Homo sapiens

Seq: 189 a.a.

Struc: 166 a.a.

Enzyme reactions

• Enzyme class: E.C.3.6.5.2 - small monomeric GTPase.
• Reaction: GTP + H2O = GDP + phosphate + H⁺

GTP + H2O = GDP (Bound ligand (Het Group name = GNP) matches with 81.82% similarity) + phosphate + H(+)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site