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PDBsum entry 8orm
Go to PDB code: 
protein ligands Protein-protein interface(s) links
Transferase PDB id
8orm

 

 

 

 

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JSmol PyMol  
Contents
Protein chains
65 a.a.
280 a.a.
288 a.a.
Ligands
V0G
Waters ×210
PDB id:
8orm
Name: Transferase
Title: Cryo-em structure of cak-thz1
Structure: Cdk-activating kinase assembly factor mat1. Chain: h. Synonym: cdk7/cyclin-h assembly factor,cyclin-g1-interacting protein, menage a trois,ring finger protein 66,ring finger protein mat1,p35, p36. Engineered: yes. Cyclin-h. Chain: i. Synonym: mo15-associated protein,p34,p37.
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mnat1, cap35, mat1, rnf66. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Gene: ccnh. Gene: cdk7, cak, cak1, cdkn7, mo15, stk1. Expression_system_taxid: 7111
Authors: V.I.Cushing,A.F.Koh,J.Feng,K.Jurgaityte,A.K.Bahl,S.Ali,A.Kotecha, B.J.Greber
Key ref: V.I.Cushing et al. High-Resolution cryo-Electron microscopy of the human cdk-Activating kinase for structure-Based drug design. To be published, . PubMed id: 38480681
Date:
14-Apr-23     Release date:   30-Aug-23    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
P51948  (MAT1_HUMAN) -  CDK-activating kinase assembly factor MAT1 from Homo sapiens
Seq:
Struc: 		309 a.a.
65 a.a.
Protein chain
Pfam   ArchSchema ?
P51946  (CCNH_HUMAN) -  Cyclin-H from Homo sapiens
Seq:
Struc: 		323 a.a.
279 a.a.
Protein chain
Pfam   ArchSchema ?
P50613  (CDK7_HUMAN) -  Cyclin-dependent kinase 7 from Homo sapiens
Seq:
Struc: 		346 a.a.
288 a.a.
Key:    PfamA domain  Secondary structure

 Enzyme reactions 
   Enzyme class 1: Chain J: E.C.2.7.11.22  - cyclin-dependent kinase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction:
1. L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H+
2. L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H+
L-seryl-[protein]
 + ATP
 = O-phospho-L-seryl-[protein]
 + ADP
 + H(+)
L-threonyl-[protein]
 + ATP
 = O-phospho-L-threonyl-[protein]
 + ADP
 + H(+)
   Enzyme class 2: Chain J: E.C.2.7.11.23  - [RNA-polymerase]-subunit kinase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: [DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H+
[DNA-directed RNA polymerase]
 + ATP
 = phospho-[DNA-directed RNA polymerase]
 + ADP
 + H(+)
Note, where more than one E.C. class is given (as above), each may correspond to a different protein domain or, in the case of polyprotein precursors, to a different mature protein.
Molecule diagrams generated from .mol files obtained from the KEGG ftp site

 

 

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