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PDBsum entry 8oge
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Metal binding protein
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PDB id
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8oge
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PDB id:
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| Name: |
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Metal binding protein
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Title:
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Structure of cobalt(ii) substituted double mutant human carbonic anhydrase ii bound to thiocyanate
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Structure:
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Carbonic anhydrase 2. Chain: a. Synonym: carbonate dehydratase ii,carbonic anhydrasE C,cac,carbonic anhydrase ii,ca-ii,cyanamide hydratase ca2. Engineered: yes. Mutation: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: ca2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008
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Resolution:
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1.46Å
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R-factor:
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0.136
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R-free:
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0.162
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Authors:
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J.M.Silva,L.Cerofolini,A.L.Carvalho,E.Ravera,M.Fragai,G.Parigi, A.L.Macedo,C.F.G.C.Geraldes,C.Luchinat
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Key ref:
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J.M.Silva
et al.
(2023).
Elucidating the concentration-Dependent effects of thiocyanate binding to carbonic anhydrase..
J.Inorg.Biochem.,
244,
12222.
PubMed id:
DOI:
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Date:
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20-Mar-23
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Release date:
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07-Feb-24
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PROCHECK
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Headers
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References
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P00918
(CAH2_HUMAN) -
Carbonic anhydrase 2 from Homo sapiens
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Seq:
Struc:
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260 a.a.
257 a.a.*
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Key: |
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PfamA domain |
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Secondary structure |
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*
PDB and UniProt seqs differ
at 1 residue position (black
cross)
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Enzyme class:
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E.C.4.2.1.1,4.2.1.69
- carbonic anhydrase.
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Reaction:
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hydrogencarbonate + H+ = CO2 + H2O
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hydrogencarbonate
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+
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H(+)
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=
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CO2
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+
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H2O
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Cofactor:
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Zn(2+)
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Links
