PDBsum entry 8ogc

Transferase

PDB id: 8ogc

Contents

Protein chain

300 a.a.

Ligands

DMS

ACT ×2

EDO

VMZ ×2

Metals

_MG

Waters ×193

PDB id:

8ogc

Name:

Transferase

Title:

Crystal structure of human dcaf1 wd40 repeats (q1250l) in complex with compound 11

Structure:

Ddb1- and cul4-associated factor 1. Chain: a. Synonym: HIV-1 vpr-binding protein,vprbp,serine/threonine-protein kinase vprbp,vpr-interacting protein. Engineered: yes. Mutation: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: dcaf1, kiaa0800, rip, vprbp. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108

Resolution:

2.09Å R-factor: 0.171 R-free: 0.202

Authors:

M.Schroeder,A.Vulpetti,M.Renatus

Key ref:

A.Vulpetti et al. Discovery of new binders for dcaf1, An emerging ligas target in the targeted protein degradation field. Acs med chem lett, . PubMed id: 37465299

Date:

19-Mar-23 Release date: 14-Jun-23

Protein chain

Q9Y4B6  (DCAF1_HUMAN) -  DDB1- and CUL4-associated factor 1 from Homo sapiens

Seq: 1507 a.a.

Struc: 300 a.a.*

* PDB and UniProt seqs differ at 1 residue position (black cross)

Enzyme reactions

• Enzyme class: E.C.2.7.11.1 - non-specific serine/threonine protein kinase.
• Reaction:
  1. L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H⁺
  2. L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site