PDBsum entry 8kcs

Membrane protein

PDB id: 8kcs

Contents

Protein chains

667 a.a.

307 a.a.

243 a.a.

96 a.a.

Ligands

NAG-NAG ×5

NAG-NAG-BMA-BMA-BMA

NAG ×6

PC1 ×2

Q70

CLR ×3

PDB id:

8kcs

Name:

Membrane protein

Title:

Cryo-em structure of human gamma-secretase in complex with bms906024

Structure:

Nicastrin. Chain: a. Engineered: yes. Presenilin-1. Chain: b. Synonym: ps-1,protein s182. Engineered: yes. Gamma-secretase subunit aph-1a. Chain: c.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: ncstn, kiaa0253, unq1874/pro4317. Expressed in: homo sapiens. Expression_system_taxid: 9606. Gene: psen1, ad3, ps1, psnl1. Gene: aph1a, psf, cgi-78, unq579/pro1141. Gene: psenen, pen2, mds033.

Authors:

X.Guo,H.Li,U.Kai,C.Yan,J.Lei,R.Zhou,Y.Shi

Key ref:

X.Guo et al. Structural basis of gamma-Secretase inhibition by anti-Cancer clinical drugs. To be published, . PubMed id: 39653842

Date:

08-Aug-23 Release date: 14-Aug-24

Protein chain

Q92542  (NICA_HUMAN) -  Nicastrin from Homo sapiens

Seq: 709 a.a.

Struc: 667 a.a.

Protein chain

P49768  (PSN1_HUMAN) -  Presenilin-1 from Homo sapiens

Seq: 467 a.a.

Struc: 307 a.a.

Protein chain

Q96BI3  (APH1A_HUMAN) -  Gamma-secretase subunit APH-1A from Homo sapiens

Seq: 265 a.a.

Struc: 243 a.a.

Protein chain

Q9NZ42  (PEN2_HUMAN) -  Gamma-secretase subunit PEN-2 from Homo sapiens

Seq: 101 a.a.

Struc: 96 a.a.

Enzyme reactions

• Enzyme class: Chain B: E.C.3.4.23.- - ?????