PDBsum entry 8jed

Transferase

PDB id: 8jed

Contents

Protein chain

296 a.a.

Waters ×178

PDB id:

8jed

Name:

Transferase

Title:

Crystal structure of mRNA cap (guanine-n7) methyltransferase e12 subunit from monkeypox virus and discovery of its inhibitors

Structure:

mRNA-capping enzyme regulatory subunit opg124. Chain: b. Synonym: virus termination factor small subunit,mRNA-capping enzyme 33 kda subunit,mRNA-capping enzyme d12 subunit,mRNA-capping enzyme small subunit. Engineered: yes

Source:

Monkeypox virus. Organism_taxid: 10244. Gene: opg124, mpxvgp109. Expressed in: escherichia coli. Expression_system_taxid: 562

Resolution:

2.16Å R-factor: 0.202 R-free: 0.254

Authors:

D.Wang,R.Zhao,W.Shu,W.Hu,M.Wang,J.Cao,X.Zhou

Key ref:

D.P.Wang et al. (2023). Crystal structure of mRNA cap (guanine-N7) methyltran e12 subunit from monkeypox virus and discovery of its inhibitors.. Int.J.Biol.Macromol., 253, 27565. PubMed id: 37866584 DOI: 10.1016/J.IJBIOMAC.2023.127565

Date:

15-May-23 Release date: 06-Dec-23

Protein chain

A0A7H0DN96  () -  mRNA-capping enzyme regulatory subunit OPG124 from Monkeypox virus

Seq: 287 a.a.

Struc: 296 a.a.*

* PDB and UniProt seqs differ at 2 residue positions (black crosses)