PDBsum entry 8izn

Transferase/viral protein

PDB id: 8izn

Contents

Protein chains

179 a.a.

122 a.a.

PDB id:

8izn

Name:

Transferase/viral protein

Title:

Structural study of interferon-induced, double-stranded RNA-activated protein kinase (pkr) and non-structural protein 1 (ns1) complex

Structure:

Interferon-induced, double-stranded RNA-activated protein kinase. Chain: a. Synonym: eukaryotic translation initiation factor 2-alpha kinase 2, eif-2a protein kinase 2,interferon-inducible RNA-dependent protein kinase,p1/eif-2a protein kinase,protein kinase RNA-activated,pkr, protein kinase r,tyrosine-protein kinase eif2ak2,p68 kinase. Engineered: yes. Non-structural protein 1.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: eif2ak2, pkr, prkr. Expressed in: escherichia coli. Expression_system_taxid: 562. Influenza a virus (strain a/memphis/102/1972 h3n2). Organism_taxid: 385640.

Authors:

C.W.Han,H.J.Kim

Key ref:

C.W.Han Structure of pkr and ns1 complex. To be published, .

Date:

07-Apr-23 Release date: 10-Apr-24

Protein chain

P19525  (E2AK2_HUMAN) -  Interferon-induced, double-stranded RNA-activated protein kinase from Homo sapiens

Seq: 551 a.a.

Struc: 179 a.a.*

Protein chain

Q463W9  (NS1_I72A3) -  Non-structural protein 1 from Influenza A virus (strain A/Memphis/102/1972 H3N2)

Seq: 220 a.a.

Struc: 122 a.a.

* PDB and UniProt seqs differ at 4 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain A: E.C.2.7.11.1,2.7.10.2 - non-specific serine/threonine protein kinase.
• Reaction:
  1. L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H⁺
  2. L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site