PDBsum entry 8hxx

Gene regulation

PDB id: 8hxx

Contents

Protein chains

549 a.a.

384 a.a.

183 a.a.

375 a.a.

156 a.a.

151 a.a.

19 a.a.

Metals

_ZN ×7

PDB id:

8hxx

Name:

Gene regulation

Title:

Cryo-em structure of the histone deacetylase complex rpd3s

Structure:

Transcriptional regulatory protein sin3. Chain: k. Engineered: yes. Histone deacetylase rpd3. Chain: l. Synonym: transcriptional regulatory protein rpd3. Engineered: yes. Chromatin modification-related protein eaf3. Chain: m, o.

Source:

Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Gene: sin3, cpe1, gam2, rpd1, sdi1, sds16, ume4, yol004w. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Gene: rpd3, mof6, rec3, sdi2, sds6, ynl330c, n0305. Gene: eaf3. Gene: rco1.

Authors:

H.Cui,H.Wang

Key ref:

H.Cui and h.wang Structure of histone deacetylase complex rpd3s bound nucleosome. Nat struct biol, . PubMed id: 37798513

Date:

05-Jan-23 Release date: 27-Sep-23

Protein chain

P22579  (SIN3_YEAST) -  Transcriptional regulatory protein SIN3 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c)

Seq: 1536 a.a.

Struc: 549 a.a.

Protein chain

P32561  (RPD3_YEAST) -  Histone deacetylase RPD3 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c)

Seq: 433 a.a.

Struc: 384 a.a.

Protein chain

Q12432  (EAF3_YEAST) -  Chromatin modification-related protein EAF3 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c)

Seq: 401 a.a.

Struc: 183 a.a.

Protein chain

Q04779  (RCO1_YEAST) -  Transcriptional regulatory protein RCO1 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c)

Seq: 684 a.a.

Struc: 375 a.a.

Protein chain

Q12432  (EAF3_YEAST) -  Chromatin modification-related protein EAF3 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c)

Seq: 401 a.a.

Struc: 156 a.a.

Protein chain

Q04779  (RCO1_YEAST) -  Transcriptional regulatory protein RCO1 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c)

Seq: 684 a.a.

Struc: 151 a.a.*

Protein chain

P84233  (H32_XENLA) -  Histone H3.2 from Xenopus laevis

Seq: 136 a.a.

Struc: 19 a.a.

* PDB and UniProt seqs differ at 46 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain L: E.C.3.5.1.98 - histone deacetylase.
• Reaction: N₆-acetyl-L-lysyl-[histone] + H2O = L-lysyl-[histone] + acetate

Molecule diagrams generated from .mol files obtained from the KEGG ftp site