PDBsum entry 8hvi

Membrane protein

PDB id: 8hvi

Contents

Protein chains

308 a.a.

214 a.a.

339 a.a.

55 a.a.

232 a.a.

Ligands

NFI

PDB id:

8hvi

Name:

Membrane protein

Title:

Activation mechanism of gpr132 by compound nox-6-7

Structure:

Soluble cytochrome b562,probable g-protein coupled receptor 132. Chain: r. Synonym: cytochrome b-562,g2 accumulation protein. Engineered: yes. Guanine nucleotide-binding protein g(i) subunit alpha-1. Chain: b. Synonym: adenylate cyclase-inhibiting g alpha protein. Engineered: yes.

Source:

Escherichia coli, homo sapiens. Human. Organism_taxid: 562, 9606. Gene: cybc, gpr132, g2a. Expressed in: baculovirus expression vector pfastbac1-hm. Expression_system_taxid: 274590. Homo sapiens. Organism_taxid: 9606. Gene: gnai1.

Authors:

J.L.Wang,J.H.Ding,J.P.Sun,X.Yu

Key ref:

J.L.Wang et al. Functional screening and rational design of compounds targeting gpr132 to treat diabetes.. Nat metab, . PubMed id: 37770763

Date:

26-Dec-22 Release date: 11-Oct-23

Protein chain

P0ABE7  (C562_ECOLX) -  Soluble cytochrome b562 from Escherichia coli

Seq: 128 a.a.

Struc: 308 a.a.*

Protein chain

Q9UNW8  (GP132_HUMAN) -  Probable G-protein coupled receptor 132 from Homo sapiens

Seq: 380 a.a.

Struc: 308 a.a.

Protein chain

P63096  (GNAI1_HUMAN) -  Guanine nucleotide-binding protein G(i) subunit alpha-1 from Homo sapiens

Seq: 354 a.a.

Struc: 214 a.a.*

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 339 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 55 a.a.

Protein chain

No UniProt id for this chain

Struc: 232 a.a.

* PDB and UniProt seqs differ at 118 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain B: E.C.3.6.5.- - ?????