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PDBsum entry 8hul
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Transcription
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PDB id
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8hul
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PDB id:
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| Name: |
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Transcription
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Title:
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X-ray structure of human ppar delta ligand binding domain-lanifibranor co-crystals obtained by co-crystallization
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Structure:
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Peroxisome proliferator-activated receptor delta. Chain: a, b. Synonym: ppar-delta,nuci,nuclear hormone receptor 1,nuc1,nuclear receptor subfamily 1 group c member 2,peroxisome proliferator- activated receptor beta,ppar-beta. Engineered: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: ppard, nr1c2, pparb. Expressed in: escherichia coli. Expression_system_taxid: 562.
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Resolution:
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2.46Å
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R-factor:
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0.213
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R-free:
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0.243
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Authors:
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S.Kamata,A.Honda,Y.Machida,K.Uchii,Y.Shiiyama,R.Masuda,T.Oyama, I.Ishii
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Key ref:
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S.Kamata
et al.
(2023).
Functional and structural insights into the human ppa / delta / gamma targeting preferences of anti-Nash investigational drugs, Lanifibranor, Seladelpar, And elafibranor.
Antioxidants,
12,
1523.
PubMed id:
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Date:
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24-Dec-22
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Release date:
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09-Aug-23
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PROCHECK
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Headers
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References
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Q03181
(PPARD_HUMAN) -
Peroxisome proliferator-activated receptor delta from Homo sapiens
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Seq:
Struc:
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441 a.a.
257 a.a.
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Key: |
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PfamA domain |
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Secondary structure |
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Links
