PDBsum entry 8hqn

Membrane protein

PDB id: 8hqn

Contents

Protein chains

296 a.a.

55 a.a.

232 a.a.

310 a.a.

214 a.a.

Ligands

9HO

PDB id:

8hqn

Name:

Membrane protein

Title:

Activation mechanism of gpr132 by 9(s)-hode

Structure:

Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1. Chain: b. Engineered: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2. Chain: c. Synonym: g gamma-i. Engineered: yes.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: gnb1. Expressed in: baculovirus expression vector pfastbac1-hm. Expression_system_taxid: 274590. Gene: gng2. Mus musculus. Organism_taxid: 10090.

Authors:

J.L.Wang,J.H.Ding,J.P.Sun,X.Yu

Key ref:

J.L.Wang et al. Functional screening and rational design of compounds targeting gpr132 to treat diabetes.. Nat metab, . PubMed id: 37770763

Date:

13-Dec-22 Release date: 11-Oct-23

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 296 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 55 a.a.

Protein chain

No UniProt id for this chain

Struc: 232 a.a.

Protein chain

P0ABE7  (C562_ECOLX) -  Soluble cytochrome b562 from Escherichia coli

Seq: 128 a.a.

Struc: 310 a.a.*

Protein chain

Q9UNW8  (GP132_HUMAN) -  Probable G-protein coupled receptor 132 from Homo sapiens

Seq: 380 a.a.

Struc: 310 a.a.

Protein chain

P63096  (GNAI1_HUMAN) -  Guanine nucleotide-binding protein G(i) subunit alpha-1 from Homo sapiens

Seq: 354 a.a.

Struc: 214 a.a.*

* PDB and UniProt seqs differ at 118 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain A: E.C.3.6.5.- - ?????