PDBsum entry 8hll

Apoptosis

PDB id: 8hll

Contents

Protein chains

194 a.a.

139 a.a.

Metals

_ZN

Waters ×6

PDB id:

8hll

Name:

Apoptosis

Title:

Crystal structure of p53/bcl2 fusion complex (complex 1)

Structure:

Cellular tumor antigen p53. Chain: a. Synonym: antigen ny-co-13,phosphoprotein p53,tumor suppressor p53. Engineered: yes. Apoptosis regulator bcl-2. Chain: b. Engineered: yes. Mutation: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: tp53, p53. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: bcl2. Expression_system_taxid: 562

Resolution:

2.62Å R-factor: 0.230 R-free: 0.280

Authors:

H.Wei,M.Guo,H.Wang,Y.Chen

Key ref:

H.Wei and y.chen Structures of p53/bcl-2 complex suggest a mechanism f to antagonize bcl-2 activity. Nat commun, . PubMed id: 37463921

Date:

30-Nov-22 Release date: 26-Jul-23

Protein chain

P04637  (P53_HUMAN) -  Cellular tumor antigen p53 from Homo sapiens

Seq: 393 a.a.

Struc: 194 a.a.

Protein chain

P10415  (BCL2_HUMAN) -  Apoptosis regulator Bcl-2 from Homo sapiens

Seq: 239 a.a.

Struc: 139 a.a.*

* PDB and UniProt seqs differ at 17 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chains A, B: E.C.?