PDBsum entry 8hj5

Signaling protein

PDB id: 8hj5

Contents

Protein chains

233 a.a.

337 a.a.

51 a.a.

232 a.a.

252 a.a.

127 a.a.

Ligands

U2U

PDB id:

8hj5

Name:

Signaling protein

Title:

Cryo-em structure of gq-coupled mrgprx1 bound with compound-16

Structure:

Guanine nucleotide-binding protein g(q) subunit alpha. Chain: a. Engineered: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1. Chain: b. Synonym: transducin beta chain 1. Engineered: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit

Source:

Homo sapiens. Organism_taxid: 9606. Gene: gnai1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Human. Gene: gnb1. Gene: gng2. Mus musculus.

Authors:

B.Gan,L.Y.Yu,R.B.Ren

Key ref:

B.Gan et al. Cryo-Em structure of gq-Coupled mrgprx1 bound with compound-16. To be published, . PubMed id: 37347749

Date:

22-Nov-22 Release date: 31-May-23

Protein chain

No UniProt id for this chain

Struc: 233 a.a.

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 337 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 51 a.a.

Protein chain

No UniProt id for this chain

Struc: 232 a.a.

Protein chain

P0ABE7  (C562_ECOLX) -  Soluble cytochrome b562 from Escherichia coli

Seq: 128 a.a.

Struc: 252 a.a.*

Protein chain

Q96LB2  (MRGX1_HUMAN) -  Mas-related G-protein coupled receptor member X1 from Homo sapiens

Seq: 322 a.a.

Struc: 252 a.a.

Protein chain

No UniProt id for this chain

Struc: 127 a.a.

* PDB and UniProt seqs differ at 119 residue positions (black crosses)