PDBsum entry 8hix

Structural protein

PDB id: 8hix

Contents

Protein chains

239 a.a.

338 a.a.

57 a.a.

126 a.a.

283 a.a.

PDB id:

8hix

Name:

Structural protein

Title:

Cryo-em structure of gpr21_m5_gs

Structure:

Guanine nucleotide-binding protein g(s) subunit alpha isoforms short. Chain: a. Synonym: adenylate cyclase-stimulating g alpha protein. Engineered: yes. Mutation: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1. Chain: b.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: gnas, gnas1, gsp. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: gnb1. Expressed in: trichoplusia ni. Expression_system_taxid: 7111.

Authors:

B.Chen,X.Lin,F.Xu

Key ref:

X.Lin et al. (2023). Cryo-Em structures of orphan gpr21 signaling complexe. Nat commun, 14, 216. PubMed id: 36639690

Date:

22-Nov-22 Release date: 15-Mar-23

Protein chain

P63092  (GNAS2_HUMAN) -  Guanine nucleotide-binding protein G(s) subunit alpha isoforms short from Homo sapiens

Seq: 394 a.a.

Struc: 239 a.a.*

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 338 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 57 a.a.

Protein chain

No UniProt id for this chain

Struc: 126 a.a.

Protein chain

Q99679  (GPR21_HUMAN) -  Probable G-protein coupled receptor 21 from Homo sapiens

Seq: 349 a.a.

Struc: 283 a.a.*

* PDB and UniProt seqs differ at 12 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain A: E.C.3.6.5.- - ?????