PDBsum entry 8hgp

Membrane protein

PDB id: 8hgp

Contents

Protein chains

563 a.a.

568 a.a.

41 a.a.

Ligands

NAG-NAG-BMA-MAN

NAG-NAG

NAG ×2

PDB id:

8hgp

Name:

Membrane protein

Title:

The ereg-bound egfr/her2 ectodomain complex

Structure:

Receptor tyrosine-protein kinase erbb-2. Chain: b. Synonym: metastatic lymph node gene 19 protein,mln 19,proto-oncogene neu,proto-oncogenE C-erbb-2,tyrosine kinase-type cell surface receptor her2,p185erbb2. Engineered: yes. Epidermal growth factor receptor. Chain: a. Synonym: proto-oncogenE C-erbb-1,receptor tyrosine-protein kinase

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: erbb2, her2, mln19, neu, ngl. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek293s gnti-. Gene: egfr, erbb, erbb1, her1. Gene: ereg.

Authors:

Z.Zhang,X.Bai

Key ref:

X.Bai et al. Strcuture and dynamics of the egfr/her2 heterodimer. To be published, . PubMed id: 36781849

Date:

15-Nov-22 Release date: 08-Feb-23

Protein chain

P04626  (ERBB2_HUMAN) -  Receptor tyrosine-protein kinase erbB-2 from Homo sapiens

Seq: 1255 a.a.

Struc: 563 a.a.

Protein chain

P00533  (EGFR_HUMAN) -  Epidermal growth factor receptor from Homo sapiens

Seq: 1210 a.a.

Struc: 568 a.a.

Protein chain

O14944  (EREG_HUMAN) -  Proepiregulin from Homo sapiens

Seq: 169 a.a.

Struc: 41 a.a.

Enzyme reactions

• Enzyme class: Chains B, A: E.C.2.7.10.1 - receptor protein-tyrosine kinase.
• Reaction: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H⁺

L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] (Bound ligand (Het Group name = NAG) matches with 41.38% similarity) + ADP + H(+)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site