PDBsum entry 8hgh

Hydrolase

PDB id: 8hgh

Contents

Protein chains

1462 a.a.

171 a.a.

Metals

_ZN ×2

PDB id:

8hgh

Name:

Hydrolase

Title:

Structure of 2:2 papp-a.Stc2 complex

Structure:

Maltose/maltodextrin-binding periplasmic protein, pappalysin-1. Chain: a, b. Synonym: mmbp,maltodextrin-binding protein,maltose-binding protein, mbp,insulin-like growth factor-dependent igf-binding protein 4 protease,igf-dependent igfbp-4 protease,igfbp-4ase,pregnancy- associated plasma protein a,papp-a. Engineered: yes. Stanniocalcin-2.

Source:

Escherichia coli k-12, homo sapiens. Human. Organism_taxid: 83333, 9606. Strain: k-12. Gene: male, b4034, jw3994, pappa. Expressed in: homo sapiens. Expression_system_taxid: 9606. Homo sapiens. Organism_taxid: 9606

Authors:

Q.H.Zhong,H.L.Chu,G.P.Wang,C.Zhang,Y.Wei,J.Qiao,J.Hang

Key ref:

Q.Zhong et al. (2022). Structural insights into the covalent regulation of p activity by prombp and stc2.. Cell discov, 8, 137. PubMed id: 36550107

Date:

14-Nov-22 Release date: 11-Jan-23

Protein chains

P0AEX9  (MALE_ECOLI) -  Maltose/maltodextrin-binding periplasmic protein from Escherichia coli (strain K12)

Seq: 396 a.a.

Struc: 1462 a.a.*

Protein chains

Q13219  (PAPP1_HUMAN) -  Pappalysin-1 from Homo sapiens

Seq: 1627 a.a.

Struc: 1462 a.a.

Protein chains

O76061  (STC2_HUMAN) -  Stanniocalcin-2 from Homo sapiens

Seq: 302 a.a.

Struc: 171 a.a.

* PDB and UniProt seqs differ at 353 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chains A, B: E.C.3.4.24.79 - pappalysin-1.
• Cofactor: Zn(2+)