PDBsum entry 8hfv

Hydrolase

PDB id: 8hfv

Contents

Protein chains

220 a.a.

Ligands

CAC ×8

0IW ×4

Metals

_ZN ×28

Waters ×636

PDB id:

8hfv

Name:

Hydrolase

Title:

Crystal structure of ctsl in complex with k777

Structure:

Procathepsin l. Chain: a, b, c, d. Synonym: cathepesin l. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: ctsl. Expressed in: escherichia coli. Expression_system_taxid: 562

Resolution:

2.10Å R-factor: 0.198 R-free: 0.242

Authors:

H.Wang,M.Shao,L.Sun,H.Yang

Key ref:

H.Wang et al. Crystal structure of ctsl in complex with k777. To be published, . PubMed id: 37990007

Date:

12-Nov-22 Release date: 13-Dec-23

Protein chains

P07711  (CATL1_HUMAN) -  Procathepsin L from Homo sapiens

Seq: 333 a.a.

Struc: 220 a.a.

Enzyme reactions

• Enzyme class: E.C.3.4.22.15 - cathepsin L.
• Reaction: Specificity close to that of papain. As compared to cathepsin B, cathepsin L exhibits higher activity towards protein substrates, but has little activity on Z-Arg-Arg-NHMec, and no peptidyl-dipeptidase activity.