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PDBsum entry 8hf8
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Nuclear protein
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PDB id
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8hf8
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PDB id:
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| Name: |
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Nuclear protein
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Title:
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Human ppar delta ligand binding domain in complex with a synthetic agonist v1
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Structure:
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Peroxisome proliferator-activated receptor delta. Chain: a, b. Fragment: activated receptor ligand binding domain. Synonym: ppar-delta,nuci,nuclear hormone receptor 1,nuc1,nuclear receptor subfamily 1 group c member 2,peroxisome proliferator- activated receptor beta,ppar-beta. Engineered: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: ppard, nr1c2, pparb. Expressed in: escherichia coli. Expression_system_taxid: 562
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Resolution:
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2.11Å
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R-factor:
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0.201
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R-free:
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0.230
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Authors:
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L.Dai,H.B.Sun,H.L.Yuan,Z.Q.Feng
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Key ref:
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Z.Feng
et al.
(2023).
Discovery of the first subnanomolar ppar alpha / delt agonist for the treatment of cholestatic liver diseas.
J.Med.Chem.,
66,
7331.
PubMed id:
DOI:
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Date:
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09-Nov-22
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Release date:
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06-Sep-23
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PROCHECK
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Headers
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References
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Q03181
(PPARD_HUMAN) -
Peroxisome proliferator-activated receptor delta from Homo sapiens
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Seq:
Struc:
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441 a.a.
262 a.a.
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Key: |
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PfamA domain |
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Secondary structure |
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Links
