PDBsum entry 8hdo

Membrane protein

PDB id: 8hdo

Contents

Protein chains

233 a.a.

334 a.a.

57 a.a.

128 a.a.

276 a.a.

Ligands

CLR ×7

I5D

PDB id:

8hdo

Name:

Membrane protein

Title:

Structure of a2br bound to synthetic agonists bay 60-6583

Structure:

Chimeric minigs. Chain: a. Synonym: adenylate cyclase-stimulating g alpha protein. Engineered: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1. Chain: b. Engineered: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: gnas, gnas1, gsp. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: gnb1. Gene: gng2. Camelus bactrianus.

Authors:

H.Cai,Y.Xu,H.E.Xu,Y.Jiang

Key ref:

H.Cai et al. (2022). Structures of adenosine receptor a 2b r bound to endo and synthetic agonists.. Cell discov, 8, 140. PubMed id: 36575181

Date:

05-Nov-22 Release date: 18-Jan-23

Protein chain

P63092  (GNAS2_HUMAN) -  Guanine nucleotide-binding protein G(s) subunit alpha isoforms short from Homo sapiens

Seq: 394 a.a.

Struc: 233 a.a.*

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 334 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 57 a.a.

Protein chain

No UniProt id for this chain

Struc: 128 a.a.

Protein chain

P29275  (AA2BR_HUMAN) -  Adenosine receptor A2b from Homo sapiens

Seq: 332 a.a.

Struc: 276 a.a.

* PDB and UniProt seqs differ at 11 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain A: E.C.3.6.5.- - ?????