PDBsum entry 8hcx

Membrane protein

PDB id: 8hcx

Contents

Protein chains

219 a.a.

338 a.a.

292 a.a.

21 a.a.

232 a.a.

57 a.a.

PDB id:

8hcx

Name:

Membrane protein

Title:

Cryo-em structure of endothelin1-bound etbr-gq complex

Structure:

Guanine nucleotide-binding protein g(q) subunit alpha-1. Chain: a. Engineered: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1. Chain: b. Synonym: transducin beta chain 1. Engineered: yes. Endothelin receptor type b,oplophorus-luciferin 2-

Source:

Homo sapiens. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Human. Gene: gnb1. Gene: ednrb, etrb. Gene: edn1. Mus musculus.

Authors:

Q.Yuan,Y.Jiang,H.E.Xu,Y.Ji,J.Duan

Key ref:

Q.Yuan et al. Cryo-Em structure of endothelin1-Bound etbr-Gq comple. To be published, . PubMed id: 36882417

Date:

03-Nov-22 Release date: 22-Mar-23

Protein chain

No UniProt id for this chain

Struc: 219 a.a.

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 338 a.a.

Protein chain

P24530  (EDNRB_HUMAN) -  Endothelin receptor type B from Homo sapiens

Seq: 442 a.a.

Struc: 292 a.a.

Protein chain

P05305  (EDN1_HUMAN) -  Endothelin-1 from Homo sapiens

Seq: 212 a.a.

Struc: 21 a.a.

Protein chain

No UniProt id for this chain

Struc: 232 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 57 a.a.

Enzyme reactions

• Enzyme class: Chain C: E.C.1.13.12.13 - Oplophorus-luciferin 2-monooxygenase.
• Pathway: Renilla-luciferin 2-monooxygenase; Watasenia-luciferin 2-monooxygenase; and Oplophorus-luciferin 2-monooxygenase
• Reaction: coelenterazine + O2 = coelenteramide + hnu + CO2

Molecule diagrams generated from .mol files obtained from the KEGG ftp site