PDBsum entry 8hch

Hydrolase

PDB id: 8hch

Contents

Protein chains

218 a.a.

Ligands

URI ×4

Metals

_MG ×4

Waters ×458

PDB id:

8hch

Name:

Hydrolase

Title:

Crystal structure of mtrex1-uridine complex

Structure:

Three-prime repair exonuclease 1. Chain: a, b, c, d. Synonym: 3'-5' exonuclease trex1. Engineered: yes

Source:

Mus musculus. House mouse. Organism_taxid: 10090. Gene: trex1. Expressed in: escherichia coli. Expression_system_taxid: 562

Resolution:

2.00Å R-factor: 0.190 R-free: 0.228

Authors:

Y.Y.Hsiao,K.W.Huang,C.Y.Wu

Key ref:

Y.Y.Hsiao et al. Molecular insight into the specific enzymatic propert trex1 revealing the diverse functions in processing r DNA/RNA hybrids.. Nucleic acids res, . PubMed id: 37870446

Date:

01-Nov-22 Release date: 08-Nov-23

Protein chains

Q91XB0  (TREX1_MOUSE) -  Three-prime repair exonuclease 1 from Mus musculus

Seq: 314 a.a.

Struc: 218 a.a.

Enzyme reactions

• Enzyme class: E.C.3.1.11.2 - exodeoxyribonuclease Iii.
• Reaction: Degradation of double-stranded DNA. It acts progressively in a 3'- to 5'-direction, releasing nucleoside 5'-phosphates.