PDBsum entry 8hbm

DNA binding protein/DNA

PDB id: 8hbm

Contents

Protein chains

79 a.a.

73 a.a.

DNA/RNA

Metals

_ZN ×8

PDB id:

8hbm

Name:

DNA binding protein/DNA

Title:

Structural basis of the farnesoid x receptor/retinoid x receptor heterodimer on inverted repeat DNA

Structure:

Retinoic acid receptor rxr-alpha. Chain: a, e. Synonym: nuclear receptor subfamily 2 group b member 1,retinoid x receptor alpha. Engineered: yes. Bile acid receptor. Chain: b, f. Synonym: farnesoid x-activated receptor,farnesol receptor hrr-1, nuclear receptor subfamily 1 group h member 4,retinoid x receptor-

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: rxra, nr2b1. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: nr1h4, bar, fxr, hrr1, rip14. Synthetic: yes. Organism_taxid: 9606

Resolution:

3.30Å R-factor: 0.253 R-free: 0.301

Authors:

L.Jiang,Y.Chen

Key ref:

L.Jiang et al. (2023). Structural basis of the farnesoid X receptor/retinoid receptor heterodimer on inverted repeat DNA. Comput struct biotechnol j, 21, 3149. PubMed id: 37287811

Date:

29-Oct-22 Release date: 14-Jun-23

Protein chains

P19793  (RXRA_HUMAN) -  Retinoic acid receptor RXR-alpha from Homo sapiens

Seq: 462 a.a.

Struc: 79 a.a.

Protein chains

Q96RI1  (NR1H4_HUMAN) -  Bile acid receptor from Homo sapiens

Seq: 486 a.a.

Struc: 73 a.a.

DNA/RNA chains

C-C-G-A-G-G-T-C-A-A-T-G-A-C-C-T-C-G 18 bases

C-C-G-A-G-G-T-C-A-T-T-G-A-C-C-T-C-G 18 bases

C-C-G-A-G-G-T-C-A-A-T-G-A-C-C-T-C-G 18 bases

C-C-G-A-G-G-T-C-A-T-T-G-A-C-C-T-C-G 18 bases

Enzyme reactions

• Enzyme class: Chains A, B, E, F: E.C.?