PDBsum entry 8hbe

Signaling protein

PDB id: 8hbe

Contents

Protein chains

542 a.a.

572 a.a.

Ligands

HEM

PDB id:

8hbe

Name:

Signaling protein

Title:

Structure of human soluble guanylate cyclase in the inactive state at 3.1 angstrom

Structure:

Guanylate cyclase soluble subunit alpha-1. Chain: a. Synonym: gcs-alpha-1,guanylate cyclase soluble subunit alpha-3,gcs- alpha-3,soluble guanylate cyclase large subunit. Engineered: yes. Other_details: genbank: aah28384.1. Guanylate cyclase soluble subunit beta-1. Chain: b. Synonym: gcs-beta-1,guanylate cyclase soluble subunit beta-3,gcs-

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: gucy1a1, guc1a3, gucsa3, gucy1a3. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: gucy1b1, guc1b3, gucsb3, gucy1b3. Expression_system_taxid: 7108

Authors:

L.Chen,R.Liu

Key ref:

R.Liu et al. (2023). No binds to the distal site of haem in the fully acti soluble guanylate cyclase.. Nitric oxide, 135, 17. PubMed id: 36972843

Date:

28-Oct-22 Release date: 19-Apr-23

Protein chain

Q02108  (GCYA1_HUMAN) -  Guanylate cyclase soluble subunit alpha-1 from Homo sapiens

Seq: 690 a.a.

Struc: 542 a.a.*

Protein chain

Q02153  (GCYB1_HUMAN) -  Guanylate cyclase soluble subunit beta-1 from Homo sapiens

Seq: 619 a.a.

Struc: 572 a.a.

* PDB and UniProt seqs differ at 1 residue position (black cross)

Enzyme reactions

• Enzyme class: Chains A, B: E.C.4.6.1.2 - guanylate cyclase.
• Reaction: GTP = 3',5'-cyclic GMP + diphosphate

Molecule diagrams generated from .mol files obtained from the KEGG ftp site