PDBsum entry 8h7h

Transferase

PDB id: 8h7h

Contents

Protein chains

269 a.a.

Ligands

QH9 ×2

Waters ×474

PDB id:

8h7h

Name:

Transferase

Title:

The crystal structure of human abl1 kinase domain in complex with abl1-a-eba

Structure:

Tyrosine-protein kinase abl1. Chain: a, b. Synonym: abelson murine leukemia viral oncogene homolog 1,abelson tyrosine-protein kinase 1,proto-oncogenE C-abl,p150. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: abl1, abl, jtk7. Expressed in: escherichia coli. Expression_system_taxid: 562

Resolution:

2.28Å R-factor: 0.185 R-free: 0.221

Authors:

C.J.Zhu,Z.M.Zhang

Key ref:

P.Chen et al. 2-Ethynylbenzaldehyde-Based, Lysine-Targeting irrever covalent inhibitors for protein kinases and nonkinase. J am chem soc, . PubMed id: 36774655

Date:

20-Oct-22 Release date: 22-Mar-23

Protein chains

P00519  (ABL1_HUMAN) -  Tyrosine-protein kinase ABL1 from Homo sapiens

Seq: 1130 a.a.

Struc: 269 a.a.

Enzyme reactions

• Enzyme class: E.C.2.7.10.2 - non-specific protein-tyrosine kinase.
• Reaction: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site