PDBsum entry 8h5c

Viral protein

PDB id: 8h5c

Contents

Protein chains

596 a.a.

195 a.a.

Ligands

NAG-NAG

NAG-NAG-FUC

NAG ×3

Metals

_ZN

PDB id:

8h5c

Name:

Viral protein

Title:

Structure of sars-cov-2 omicron ba.2.75 rbd in complex with human ace2

Structure:

Processed angiotensin-converting enzyme 2. Chain: a. Engineered: yes. Spike protein s1. Chain: b. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: ace2, unq868/pro1885. Expressed in: homo sapiens. Expression_system_taxid: 9606. Severe acute respiratory syndrome coronavirus 2. Organism_taxid: 2697049.

Resolution:

2.90Å R-factor: 0.199 R-free: 0.242

Authors:

Z.N.Zhao,B.Bai,K.F.Liu,J.X.Qi,G.F.Gao

Key ref:

Z.N.Zhao et al. Structure of sars-Cov-2 omicron ba.2.75 rbd in comple human ace2. To be published, . PubMed id: 37479708

Date:

12-Oct-22 Release date: 19-Jul-23

Protein chain

Q9BYF1  (ACE2_HUMAN) -  Angiotensin-converting enzyme 2 from Homo sapiens

Seq: 805 a.a.

Struc: 596 a.a.

Protein chain

P0DTC2  (SPIKE_SARS2) -  Spike glycoprotein from Severe acute respiratory syndrome coronavirus 2

Seq: 1273 a.a.

Struc: 195 a.a.*

* PDB and UniProt seqs differ at 17 residue positions (black crosses)

Enzyme reactions

• Enzyme class 1: Chain A: E.C.3.4.17.- - ?????
• Enzyme class 2: Chain A: E.C.3.4.17.23 - angiotensin-converting enzyme 2.
• Reaction: angiotensin II + H2O = angiotensin-^1-7 + L-phenylalanine

angiotensin II + H2O = angiotensin-(1-7) + L-phenylalanine (Bound ligand (Het Group name = NAG) matches with 44.44% similarity)

Note, where more than one E.C. class is given (as above), each may correspond to a different protein domain or, in the case of polyprotein precursors, to a different mature protein.

Molecule diagrams generated from .mol files obtained from the KEGG ftp site