PDBsum entry 8h3l

Viral protein

PDB id: 8h3l

Contents

Protein chains

302 a.a.

Ligands

7YY ×4

Waters ×312

PDB id:

8h3l

Name:

Viral protein

Title:

Crystal structure of sars-cov-2 main protease (mpro) double mutant (t21i and e166v) in complex with inhibitor enstrelvir

Structure:

3c-like proteinase nsp5. Chain: a, b, c, d. Synonym: 3cl-pro,3clp,main protease,mpro,non-structural protein 5, nsp5,sars coronavirus main proteinase. Engineered: yes. Mutation: yes

Source:

Severe acute respiratory syndrome coronavirus 2. 2019-ncov, sars-cov-2. Organism_taxid: 2697049. Expressed in: escherichia coli. Expression_system_taxid: 562

Resolution:

2.30Å R-factor: 0.207 R-free: 0.231

Authors:

H.Wang,M.Lin,Y.Duan,X.Zhang,H.Zhou,Q.Bian,X.Liu,Z.Rao,H.Yang

Key ref:

Y.Duan et al. Molecular mechanisms of sars-Cov-2 resistance to nirmatrelvir.. Nature, . PubMed id: 37696289

Date:

08-Oct-22 Release date: 11-Oct-23

Protein chains

P0DTD1  (R1AB_SARS2) -

Enzyme reactions

• Enzyme class: E.C.3.4.22.69 - Sars coronavirus main proteinase.