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PDBsum entry 8guj
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protein dna_rna metals Protein-protein interface(s) links
Gene regulation/DNA PDB id
8guj

 

 

 

 

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Contents
Protein chains
98 a.a.
82 a.a.
112 a.a.
96 a.a.
72 a.a.
73 a.a.
DNA/RNA
Metals
_ZN ×4
PDB id:
8guj
Name: Gene regulation/DNA
Title: Bre1-nucleosome complex (model ii)
Structure: Histone h3.1. Chain: a, e. Engineered: yes. Histone h4. Chain: b, f. Engineered: yes. Histone h2a type 1. Chain: c, g. Synonym: h2a.1,histone h2a/ptl.
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: h2ac11, h2afp, hist1h2ag, h2ac13, h2afc, hist1h2ai, h2ac15, h2afd, hist1h2ak, h2ac16, h2afi, hist1h2al, h2ac17, h2afn, hist1h2am. Gene: h2bc11, h2bfr, hist1h2bj.
Authors: S.Onishi,K.Sato,K.Hamada,T.Nishizawa,O.Nureki,K.Ogata,T.Sengoku
Key ref: S.Onishi et al. Structure of the human bre1 complex bound to the nucl. To be published, . PubMed id: 38519511
Date:
12-Sep-22     Release date:   20-Sep-23    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chains
P68431  (H31_HUMAN) -  Histone H3.1 from Homo sapiens
Seq:
Struc: 		136 a.a.
98 a.a.
Protein chains
P62805  (H4_HUMAN) -  Histone H4 from Homo sapiens
Seq:
Struc: 		103 a.a.
82 a.a.
Protein chains
P0C0S8  (H2A1_HUMAN) -  Histone H2A type 1 from Homo sapiens
Seq:
Struc: 		130 a.a.
112 a.a.
Protein chains
P06899  (H2B1J_HUMAN) -  Histone H2B type 1-J from Homo sapiens
Seq:
Struc: 		126 a.a.
96 a.a.
Protein chain
Q5VTR2  (BRE1A_HUMAN) -  E3 ubiquitin-protein ligase BRE1A from Homo sapiens
Seq:
Struc: 		 
Seq:
Struc: 		975 a.a.
72 a.a.
Protein chain
O75150  (BRE1B_HUMAN) -  E3 ubiquitin-protein ligase BRE1B from Homo sapiens
Seq:
Struc: 		 
Seq:
Struc: 		1001 a.a.
73 a.a.
Key:    Secondary structure

DNA/RNA chains
  C-T-G-G-A-G-A-A-T-C-C-C-G-G-T-G-C-C-G-A-G-G-C-C-G-C-T-C-A-A-T-T-G-G-T-C-G-T-A- 147 bases
  A-C-A-G-G-A-T-G-T-A-T-A-T-A-T-C-T-G-A-C-A-C-G-T-G-C-C-T-G-G-A-G-A-C-T-A-G-G-G- 147 bases

 Enzyme reactions 
   Enzyme class: Chains K, L: E.C.2.3.2.27  - RING-type E3 ubiquitin transferase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6- ubiquitinyl-[acceptor protein]-L-lysine

 

 

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