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PDBsum entry 8fv4
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PDB id:
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Transferase
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Title:
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Egfr(t790m/v948r) in complex with compound 2 (ln5993)
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Structure:
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Epidermal growth factor receptor. Chain: d, a, b, c. Synonym: proto-oncogenE C-erbb-1,receptor tyrosine-protein kinase erbb-1. Engineered: yes. Mutation: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
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Resolution:
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2.20Å
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R-factor:
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0.204
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R-free:
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0.261
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Authors:
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B.C.Ogboo,T.S.Beyett,M.J.Eck,D.E.Heppner
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Key ref:
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B.C.Ogboo
et al.
Egfr(t790m/V948r) in complex with compound 2 (ln5993).
To be published,
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PubMed id:
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Date:
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18-Jan-23
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Release date:
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17-Jan-24
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PROCHECK
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Headers
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References
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P00533
(EGFR_HUMAN) -
Epidermal growth factor receptor from Homo sapiens
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Seq:
Struc:
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1210 a.a.
291 a.a.*
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Key: |
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PfamA domain |
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Secondary structure |
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*
PDB and UniProt seqs differ
at 2 residue positions (black
crosses)
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Enzyme class:
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E.C.2.7.10.1
- receptor protein-tyrosine kinase.
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Reaction:
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L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H+
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L-tyrosyl-[protein]
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+
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ATP
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=
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O-phospho-L-tyrosyl-[protein]
Bound ligand (Het Group name = )
matches with 81.25% similarity
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+
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ADP
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+
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H(+)
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Links
