PDBsum entry 8fmz

Membrane protein

PDB id: 8fmz

Contents

Protein chains

221 a.a.

338 a.a.

51 a.a.

230 a.a.

280 a.a.

Ligands

ARG-ARG-PRO-TYR-ILE-LEU

PDB id:

8fmz

Name:

Membrane protein

Title:

Neurotensin receptor allosterism revealed in complex with a biased allosteric modulator

Structure:

Minigq. Chain: b. Engineered: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1. Chain: c. Synonym: transducin beta chain 1. Engineered: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit

Source:

Escherichia coli. Organism_taxid: 562. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Homo sapiens. Human. Organism_taxid: 9606. Gene: gnb1. Gene: gng2.

Authors:

B.E.Krumm,J.F.Diberto,R.H.J.Olsen,H.Kang,S.T.Slocum,S.Zhang, R.T.Strachan,J.F.Fay,B.L.Roth

Key ref:

B.E.Krumm et al. Neurotensin receptor allosterism revealed in complex biased allosteric modulator.. Biochemistry, . PubMed id: 36917754

Date:

26-Dec-22 Release date: 29-Mar-23

Protein chain

No UniProt id for this chain

Struc: 221 a.a.

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 338 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 51 a.a.

Protein chain

No UniProt id for this chain

Struc: 230 a.a.

Protein chain

P20789  (NTR1_RAT) -  Neurotensin receptor type 1 from Rattus norvegicus

Seq: 424 a.a.

Struc: 280 a.a.*

* PDB and UniProt seqs differ at 3 residue positions (black crosses)