PDBsum entry 8fe3

Virus/immune system

PDB id: 8fe3

Contents

Protein chains

226 a.a.

215 a.a.

386 a.a.

80 a.a.

PDB id:

8fe3

Name:

Virus/immune system

Title:

Structure of dengue virus (denv2) in complex with prm12, an anti-prm monoclonal antibody

Structure:

Prm12 fab heavy chain. Chain: h, m, o. Engineered: yes. Other_details: the homology model of the prm12 variable heavy chain domain (1-124) was pieced together with the crystal structure of the constant heavy chain domain, derived from zv-67, which belongs to murine igg2c isotype similar to prm12.. Prm12 fab light chain. Chain: l, n, p.

Source:

Mus musculus. Mouse. Organism_taxid: 10090. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek293t/17. Expression_system_atcc_number: crl-11268. Dengue virus type 2. Organism_taxid: 11060.

Authors:

A.D.Dowd,D.Sirohi,S.Speer,S.Mukherjee,J.Govero,M.Aleshnick,B.Larman, S.Sukupolvi-Petty,M.Sevvana,A.S.Miller,T.Klose,A.Zheng,M.Kielian, R.J.Kuhn,M.S.Diamond,T.C.Pierson

Key ref:

K.A dowd et al. (2023). Prm-Reactive antibodies reveal a role for partially m virions in dengue virus pathogenesis.. Proc natl acad sci usa, 120, 99120. PubMed id: 36638211

Date:

05-Dec-22 Release date: 01-Feb-23

Protein chains

No UniProt id for this chain

Struc: 226 a.a.

Protein chains

No UniProt id for this chain

Struc: 215 a.a.

Protein chains

E7FLK7  (E7FLK7_9FLAV) -  Genome polyprotein (Fragment) from dengue virus type 2

Seq: 1134 a.a.

Struc: 386 a.a.*

Protein chains

E7FLK7  (E7FLK7_9FLAV) -  Genome polyprotein (Fragment) from dengue virus type 2

Seq: 1134 a.a.

Struc: 80 a.a.

* PDB and UniProt seqs differ at 2 residue positions (black crosses)