PDBsum entry 8faj

Hydrolase/inhibitor

PDB id: 8faj

Contents

Protein chains

244 a.a.

Ligands

Y33 ×2

Metals

_CL ×4

_CA ×3

_CD ×2

Waters ×273

PDB id:

8faj

Name:

Hydrolase/inhibitor

Title:

Oxa-48-na-1-157 inhibitor complex

Structure:

Beta-lactamase. Chain: a, b. Engineered: yes

Source:

Klebsiella pneumoniae. Organism_taxid: 573. Gene: bla oxa-48, blaoxa-48, kpe71t_00045. Expressed in: escherichia coli. Expression_system_taxid: 562

Resolution:

1.75Å R-factor: 0.183 R-free: 0.216

Authors:

C.A.Smith,N.K.Stewart,M.Toth,S.B.Vakulenko

Key ref:

C.A.Smith et al. (2023). The c5 alpha-Methyl-Substituted carbapenem na-1-157 e potent activity against klebsiella spp. Isolates prod oxa-48-Type carbapenemases.. Acs infect dis, 9, 1123. PubMed id: 37130087

Date:

28-Nov-22 Release date: 11-Oct-23

Protein chains

Q6XEC0  (BLO48_KLEPN) -  Beta-lactamase OXA-48 from Klebsiella pneumoniae

Seq: 265 a.a.

Struc: 244 a.a.

Enzyme reactions

• Enzyme class: E.C.3.5.2.6 - beta-lactamase.
• Pathway: Penicillin Biosynthesis and Metabolism
• Reaction: a beta-lactam + H2O = a substituted beta-amino acid
• Cofactor: Zn(2+)